If you are not redirected, this is the full content for search engines and no‑JS browsers.

Our NAMs Refinement Service is designed for teams who already have a working NAM and want to repurpose it for use in a new way—another organ system, a different exposure window, a new disease context, or a more complex combination of stressors. Instead of rebuilding your method, we focus on tuning it: testing that it still performs well, where it needs adjustment, and how the limits of its reliable use should be drawn. Working with you, we design targeted *in vivo* "bridging" studies that mirror the new conditions you have in mind. Using relevant *in vivo* models, we adjust parameters such as dose, timing, environmental or physiological conditions, and readouts, then compare those results to your NAM's outputs. This side-by-side view helps clarify how your repurposed NAM behaves in a new context, whether any recalibration is needed, and what boundaries should be documented for responsible use. All study designs and data stay with your team, and the outcome is a clearer map of where your NAM can be confidently extended—and where it should not be pushed without additional work. Refinement lets you get more value from methods you already trust, while keeping their expanded use grounded in real biology and aligned with 3R principles.